Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO)

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1024-1029. doi: 10.1016/j.bmcl.2018.02.027. Epub 2018 Feb 14.

Abstract

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Catalytic Domain / drug effects
  • Dose-Response Relationship, Drug
  • Drug Design*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Heme Oxygenase (Decyclizing) / antagonists & inhibitors*
  • Heme Oxygenase (Decyclizing) / metabolism
  • Molecular Structure
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Heme Oxygenase (Decyclizing)